MORPHOGENESIS OF TUMORAL GROWTH AT CORRECTION BY MELATONINE AND METFORMINE 

Deryabina Ol'ga Nikolaevna, Candidate of medical sciences, assistant, sub-department of oncology with a course of radiodiagnostics and radiation therapy, Ogarev Mordovia State University
(68 Bolshevistskaya street, Saransk, Russia), dr.deryabina@gmail.com
Plotnikova Nadezhda Alekseevna, Doctor of medical sciences, professor, head of sub-department of pathology, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), plona@mail.ru
Kanaev Pavel Mikhaylovich, Postgraduate student, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), kpm1983@bk.ru

616-006.04

Background. The article aims at studying the influence of melatonine and met-formine at separate and combined application on the carcinogenesis of skin induced by benzo[a]pyrene at mice.
Materials and methods. 120 mice were divided into 4 groups: 3 experimental groups of 30 mice in each, 30 animals – a control group of carcinogen. To animals of all four groups the authors introduced benzo[a]pyrene in a dose of 0,2 ml per mouse two times a week. Calculation of total number of tumoral knots of skin was made, the sizes thereof were defined.
Results. It is established that at histologic research the authors observed the pat-tern, typical for a planocellulare cornescens cancer and skin papillomas in the control group and in the groups receiving melatonine and metformine. The number of ani-mals with histologically verified papillomas of skin totaled 27 % in control. In case of melatonine introduction – 30 %, at introduction of metformine – 40 %, at joint use of melatonine and metformine – 30 %. At melatonine introduction the number of animals with malignant tumors totaled 37 %, at melatonine application together with metformine the percentage totaled 20 %.
Conclusions. The received results testify that melatonine and metformine have an expressed oncostatic effect displayed in reduction of plurality, the sizes of tumoral knots.

induced carcinogenesis, melanoma, preparations of metabolic effect.

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